Tongbi-san can be used to treat obesity, thanks to its ability to inhibit adipogenesis in the liver

Friday, May 10, 2019 by

Researchers from Sangji University in South Korea investigated the effects of a traditional medicine known as tongbi-san on obesity. The results of their study were published in the journal BMC Complementary and Alternative Medicine.

  • Tongbi-san contains three herbs, nut grass (Cyperus rotundus L.), satsuma mandarin (Citrus unshiu), and China root (Poria cocos).
  • The researchers tested tongbi-san’s ability to inhibit adipogenesis in the liver and epididymal adipose tissue of obese mice.
  • To induce obesity, they fed mice with a high-fat diet for 11 weeks.
  • Some mice also received orlistat or tongbi-san, while others did not receive any treatment.
  • The researchers measured the mice’s weight every week and performed histological tissue examinations at the end of the observation period. They also assessed the expression of genes involved in adipogenesis.
  • The researchers reported that oral supplementation of tongbi-san dramatically reduced the mice’s body weight and reduced epididymal and visceral white adipose tissue weight.
  • It also increased the expression of adenosine monophosphate-activated protein kinase (AMPK) and inhibited the expression of transcription factors in the liver and epididymal white adipose tissue.
  • These results indicated that tongbi-san treatment could inhibit adipogenesis by regulating lipid accumulation and adipogenic-related factors in obese mice.

Based on their findings, the researchers concluded that tongbi-san has an inhibitory effect on adipogenesis and may be used as a treatment for obesity.

Visit FightObesity.news to learn more about other alternative treatments for obesity.

Read the full study at this link.

Journal Reference:

Park YJ, Lee GS, Cheon SY, Cha YY, An HY. THE ANTI-OBESITY EFFECTS OF TONGBI-SAN IN A HIGH-FAT DIET-INDUCED OBESE MOUSE MODEL. BMC Complementary and Alternative Medicine. 3 January 2019;19:1. DOI: 10.1186/s12906-018-2420-5



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